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what version of ESXi?<br />
<br />
try using vmkping (from the ESXi hosts) with a lower mtu as a test
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what version of ESXi?

try using vmkping (from the ESXi hosts) with a lower mtu as a test

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* &nbsp;VMware VDS is Set with Load balancing Mode – Source and destination IP Adress , TCP/UDP port and VLAN .<br />
* Storage is NFS Traffic &nbsp;with Jumbo Frames &nbsp;. NetAPP CDOT<br />
* Assuming Nexus is setup properly <br />
* NFS Traffic layer 2 no gateway required<br />
* ESXI Server can ping &nbsp;NETApp lifs by jumbo <br />
* NetApp cannot &nbsp;ping back Esxi Hosts on Jumbo <br />
<br />
On the Nexus Switches , what is the recommended settings &nbsp;for the &nbsp;ESXi Hosts ? I don't necessarily need the command set but recommended settings <br />
<br />
IE : Turn off Spanning &nbsp;Tree ?
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*  VMware VDS is Set with Load balancing Mode – Source and destination IP Adress , TCP/UDP port and VLAN .
* Storage is NFS Traffic  with Jumbo Frames  . NetAPP CDOT
* Assuming Nexus is setup properly 
* NFS Traffic layer 2 no gateway required
* ESXI Server can ping  NETApp lifs by jumbo 
* NetApp cannot  ping back Esxi Hosts on Jumbo 

On the Nexus Switches , what is the recommended settings  for the  ESXi Hosts ? I don't necessarily need the command set but recommended settings 

IE : Turn off Spanning  Tree ?

VMware Esxi 5.5  Enhanced  LACP LAG  with Nexus Switching plus NetApp LACP LAG

VMware, a software company founded in 1998,  was one of the first commercially successful companies to offer x86 virtualization. The storage company EMC purchased VMware in 1994. Dell Technologies acquired EMC in 2016. VMware’s parent company is now Dell Technologies.

VMware has many software products that run on desktops, Microsoft Windows, Linux, and macOS, which allows the virtualizing of the x86 architecture.  Its enterprise software hypervisor for servers, VMware vSphere Hypervisor (ESXi), is a bare-metal hypervisor that runs directly on the server hardware and does not require an additional underlying operating system.

VMware

Networking is the process of connecting computing devices, peripherals and terminals together through a system that uses wiring, cabling or radio waves that enable their users to communicate, share information and interact over distances. Often associated are issues regarding operating systems, hardware and equipment, cloud and virtual networking, protocols, architecture, storage and management.