SBS 2008 locking up and failing

We have a client with SBS 2008 and the server will not work properly. We can only log in with the last account that logged in and no local accounts will work when we try them. Windows Explorer will not open, no Windows modules we try will open, not even Control Panel or anything like that. Since the only account that can log in is a domain account we are not able to log in safe mode because it says that there are no logon servers available since the service is not running, more than likely.

We have confirmed that the physical drives in the RAID 1 passed SMART tests.
We have run a consistency check on the logical drive and that came back clean
We are in the process of running a chkdsk from a boot environment to see if repairing the logical drive system files will do any good. If that doesn't work we will be backing up the system and trying a repair Windows via the installation  media.

Are there any further steps you can suggest aside from blowing it out and starting all over?
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Scott CSenior EngineerCommented:
A repair or reinstall at this point is your only option.

It looks like the system files are either corrupted or infected.

No full backup of the system before the problem started?

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Is it out of disk space?
It is a domain controller so there will not be local accounts
Login with another admin account, see if that makes a difference
PIMSupportAuthor Commented:
No environmental backup on this server, offsite data backup only.

Plenty of disk space still available

not able to get into via another admin account
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Scott CSenior EngineerCommented:
I think at this point you're looking at a rebuild of the system and recover the data from the backups.
David AtkinTechnical DirectorCommented:
Have you tried Safe Mode with Networking?

Is this problem intermittent and does a reboot bring it back online for any period of time?

It sounds like it could possibly be a memory leak causing the server to slow and eventually services to crash.
PIMSupportAuthor Commented:
The server was beyond repair and the age of it put it out of a reinstall scenario. They purchased a new server with 2012 R2 standard and we migrated their email to Exchange hosted with 365
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