iSCSI conflict (SBS 2011 Server)

We have a Microsoft SBS 2011 network with an HP Server with 5 NICs, all fully patched.

We have an iSCSI Drobo for backup that I want on a different range for security/visibility.

The main network is on 192.168.1.X
If I put the Drobo on 10.0.0.Y the network starts to run slow after a while.
If I disable that NIC sanity is restored.

Could someone point me in the direction of best/working practice for attaching iSCSIs?
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Andrej PirmanCommented:
iSCSI has problems on multipathing, even if there's proper driver on server side, handling more than 1 NIC in a virtual NIC. So if you have network 10.0.0.x configured on virtual NIC, which uses 2 or more physical NIC adapters, this might be your problem.
Does this sound like your problem?

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David AtkinTechnical DirectorCommented:
Strictly speaking SBS only supports a single NIC by design.  Having more than one active NIC tends to cause all sorts of issues in my experience.
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