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SCCM2012 R2 CU3 No space on C drive

Last Modified: 2015-11-30
Hi there,
I am running SCCM2012 R2 CU3 with my deployment folder on C as well on this SCCM2012 R2 CU3 under C drive the folder SCCMContentLib is getting about 362GB in size
it has 3 folders FileLib(362GB), DataLib(24MB, and PkgLib(312KB).  The FIleLib folder has:
3Files and many folders.  THe 3 files are:
TD81C0000A = 44GB
TE4140000A = 20GB
T841B0000A = 17.8GB

3C42 = 45GB
F0F1 = 45GB
6900 = 44GB
3D2D = 36GB
D3E2 = 21GB  and so on.

I am trying to create some free space on my SCCM 2012 as it is covering more than 1TB.  Can I delete the folders and files above? or what am I looking for to delete them securely not interefering with my SCCM2012 system.  
My deployments have stopped working clearly I have no space on my C drive.  Need help.
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