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I don't think it's the size of the database, you most like have some corruption or inconsistencies.<br />
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You can run ISINTEG and ESEUTIL to try to correct any problems.<br />
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<a href="https://technet.microsoft.com/en-us/library/aa996436(v=exchg.65).aspx" rel="ugc">https://technet.microsoft.com/en-us/library/aa996436(v=exchg.65).aspx</a><br />
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These would have to be done offline and you'd need 2.5 times the size of your DB available to run these.<br />
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Also in a best case scenario you will process about 10 gig an hour.<br />
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When I was with MS as a Tier 3 Exchange Engineer I saw larger databases than that and they ran with no issues.
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The one response received did not help to resolve the question. I researched the matter &amp;&nbsp;resolved.
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All Outlook users are intermittently (twice this week) receive “The Microsoft Exchange Administrator has made a change that requires you quit and restart Outlook.” error. OWA access stops working.<br />
<br />
Restarting Exchange Information Store service removes the error for the time being.<br />
<br />
I've read several posts in EE regarding this &amp;&nbsp;believe that this is related to the size of the exchange EDB file.<br />
server: SBS2008/Exchange2007<br />
size of EDB file : 264,342,672 KB<br />
<br />
Not absolutely sure but this seems to occur around 6am when an incremental backup is taken. <br />
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I'm in the process of removing some old mailboxes so that edb doesn't expand further.<br />
<br />
what do you suggest to confirm that the size issue is indeed the problem?<br />
<br />
what steps to resolve the problem?<br />
<br />
thanks<br />
Jay
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All Outlook users are intermittently (twice this week) receive “The Microsoft Exchange Administrator has made a change that requires you quit and restart Outlook.” error. OWA access stops working.

Restarting Exchange Information Store service removes the error for the time being.

I've read several posts in EE regarding this & believe that this is related to the size of the exchange EDB file.
server: SBS2008/Exchange2007
size of EDB file : 264,342,672 KB

Not absolutely sure but this seems to occur around 6am when an incremental backup is taken. 

I'm in the process of removing some old mailboxes so that edb doesn't expand further.

what do you suggest to confirm that the size issue is indeed the problem?

what steps to resolve the problem?

thanks
Jay

All outlook users getting “The Microsoft Exchange Administrator has made a change...” error, temp rsolved by restarting Exch Info Store service

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.

Outlook

Small Business Server (SBS) is a line of server operating systems targeted at small businesses by bundling the operating system with a number of other Microsoft products that would normally need to be purchased or licensed separately. The most notable inclusions are Exchange, SQL Server, SharePoint and ISA/TMG (Microsoft's firewall and proxy server).