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Check your URLs. &nbsp;<br />
<br />
Get-ActiveSyncVirtualDirec<wbr />tory &nbsp; | ft server,*lur* -AutoSize<br />
Get-AutodiscoverVirtualDir<wbr />ectory | ft server,*lur* -AutoSize<br />
Get-ClientAccessServer &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; | ft name, &nbsp;*lur* -AutoSize<br />
Get-EcpVirtualDirectory &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;| ft server,*lur* -AutoSize<br />
Get-OabVirtualDirectory &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;| ft server,*lur* -AutoSize<br />
Get-OwaVirtualDirectory &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;| ft server,*lur* -AutoSize<br />
Get-WebServicesVirtualDire<wbr />ctory &nbsp;| ft server,*lur* -AutoSize<br />
<br />
If they are correct, delete the Outlook profile and recreate.<br />
<br />
AutoDiscover is the one you want to look at.<br />
<br />
Also make sure the EWS is correct. mail.domain.com/ews/exchan<wbr />ge.asmx<br />
<br />
Make sure your cert is correct as well.<br />
<br />
Get-ExchangeCertificate | fl
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Here is a sample of the URLs from one of my labs.<br />
<br />
You also want to do a:<br />
<br />
Test-OutlookWebServices &nbsp;| ft<br />
<br />
<a href="https://technet.microsoft.com/en-us/library/bb124509(v=exchg.141).aspx" rel="ugc">https://technet.microsoft.com/en-us/library/bb124509(v=exchg.141).aspx</a><br />
<br />
All should come back as &quot;Information&quot; or &quot;Success&quot;.<br />
<a href="https://filedb.experts-exchange.com/incoming/2015/12_w52/1058326/CaptureURLs.JPG" target="_blank" class="file-inline" title="URLs for Exchange (112 KB)"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path d="M67.508 468.467c-58.005-58.013-58.016-151.92 0-209.943l225.011-225.04c44.643-44.645 117.279-44.645 161.92 0 44.743 44.749 44.753 117.186 0 161.944l-189.465 189.49c-31.41 31.413-82.518 31.412-113.926.001-31.479-31.482-31.49-82.453 0-113.944L311.51 110.491c4.687-4.687 12.286-4.687 16.972 0l16.967 16.971c4.685 4.686 4.685 12.283 0 16.969L184.983 304.917c-12.724 12.724-12.73 33.328 0 46.058 12.696 12.697 33.356 12.699 46.054-.001l189.465-189.489c25.987-25.989 25.994-68.06.001-94.056-25.931-25.934-68.119-25.932-94.049 0l-225.01 225.039c-39.249 39.252-39.258 102.795-.001 142.057 39.285 39.29 102.885 39.287 142.162-.028A739446.174 739446.174 0 0 1 439.497 238.49c4.686-4.687 12.282-4.684 16.969.004l16.967 16.971c4.685 4.686 4.689 12.279.004 16.965a755654.128 755654.128 0 0 0-195.881 195.996c-58.034 58.092-152.004 58.093-210.048.041z"/></svg>CaptureURLs.JPG</a>
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CaptureURLs.JPG

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Please read my recently accepted answer for this issue in another EE question..<br />
<br />
<a href="https://www.experts-exchange.com/questions/28744162/Exchange-2010-Cert-issue.html" rel="ugc">EE Accepted Solution to this problem</a>
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I have an Exchange 2003 server and Outlook 2010 clients. &nbsp;The new cert is for mail.domain.com. &nbsp;Outlook is looking for mail.domain.local and is coming up with a cert error. &nbsp;How do I tell outlook to look for the .com.
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I have an Exchange 2003 server and Outlook 2010 clients.  The new cert is for mail.domain.com.  Outlook is looking for mail.domain.local and is coming up with a cert error.  How do I tell outlook to look for the .com.

Outlook 2010 is looking for mail.domain.local instead of mail.domain.com after new cert. exchange 2003 is server

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

An email client, email reader or more formally mail user agent (MUA) is a computer program in the category of groupware environments used to access and manage a user's email. A web application that provides message management, composition, and reception functions may internally act as an email client; as a whole, it is commonly referred to as webmail. Likewise, email client may be referred to a piece of computer hardware or software whose primary or most visible role is to work as an email client. Email clients can also have other systems, like calendars, notes and contact managers.

Email Clients

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.