Windows cannot log you on because your profile cannot be loaded. - Terminal Server login issue

Hi All,

Can anyone here please assist me with what's the cause or how to prevent this problem where user cannot login to the Windows Server 2008 R2 Terminal Server (RDSH) ?

This is the error logged:

Log Name:      Application
Source:        Microsoft-Windows-User Profiles Service
Date:          22/12/2015 7:57:44 AM
Event ID:      1500
Task Category: None
Level:         Error
Keywords:      
User:          DOMAIN\hk-mgr
Computer:      PRODTS01-VM.DOMAIN.com
Description:
Windows cannot log you on because your profile cannot be loaded. 
Check that you are connected to the network, and that your network is functioning correctly. 

 DETAIL - The system cannot find the file specified.

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and this is what the users see when they cannot logon:

Any help would be greatly appreciated.

Thanks