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2008 R2 RDS Infrastructure Guidance

We are investigating setting up an RDS server with 20 user CALs.
The question I have is... can I set it up RDS on a new instance of 2008 R2, running in a Hyper-V VM if I dedicate enough resources to it?
My google-fu must be slipping, because I keep coming across conflicting answers.
We already have a big 2008 R2 enterprise server in our COLO with a lot of beef in it, so spinning up another VM with a ton of CPU and RAM is not that big of a deal.
Is this possible, or does it violate laws of physics?
Am I about to divide my server by zero?

Thanks in advance!
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Mohammed Khawaja
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What applications will be running on the RDSH?

In a Hyper-V setting our general rule of thumb is 512MB to 768MB of vRAM per user. If they are heavy on the browsers then bump that up.

Start with 2 vCPUs and test.

Note that performance can be impacted by assigning more vRAM that spans more than 1 NUMA node and also more vCPUs then there are physical cores on one CPU socket.