Windows 7 user strange issue - settings cleared and everything in the recycle bin

Have a strange issue where a user left for a couple months and hadn't logged onto their computer, they come back and login and all their wallpaper, start menu/taskbar shortcuts disappear. Everything they  had on their desktop or profile folders like documents, was sitting in the recycle bin.  
Any idea what could have triggered that?
garryshapeAsked:
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mbkitmgrCommented:
Malware ? - I could be wrong but I had a client who had the same symptoms and malwarebytes picked up an infection.  The infection was confined to the users profile, and because they didn't have admin rights, confined the damage to the logged in user

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garryshapeAuthor Commented:
The user is a domain admin; all users are domain admins
garryshapeAuthor Commented:
Just kidding.
But I suspect malware or lack of information from people who use that system.
Annoying that dumb stuff like that triggers hours of my time to "investigate", however.
mbkitmgrCommented:
You got me... got me good - I sat here going OMG..... OMFG....  :)
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Windows 7

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