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Running Outlook in Cache model or not

sglee asked
Last Modified: 2016-04-26
 I have SBS2011/Exchange Server 2010 and Outlook 2013.
 I have been enabling Cache mode whenever I set up Outlook on user computers for safety just in case Exchange Server (20 mailbox database > 200GB in size) crashes  or not available for extended period of time.
 The downside of that is, from time to time, local copy username@domain.com.OST file gets corrupted as some user mailbox size exceeds 20GB. (I know max size for OST is 50GB) Sometimes it takes a long time to open Outlook (maybe because Outlook has to sync its local contents against Exchange Server before opening Outlook?).
 Whenever the problem occurs, I simply delete existing OST file and re-open Outlook so that new OST is created. The inconvenience is that users complain that they can't perform search until indexing to complete.

When you perform a search in Outlook, does it make a difference whether Outlook is running in Cache mode or not?
 I just like to get know how other experts are managing Outlook data.
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