Access Denied Contact Your Administrator

We have users with Office 2016 installed on 7 computers.  There is an issue with saving files on a network share Windows Server 2012.  If they open an Excel or Word file and make changes and save it, they get the error access denied contact your administrator.  They can create new documents and save it but once they add additional changes they get the message and the file may even disappear from the share after trying to save it.

Any suggestions I need to get this fixed asap so whatever suggestions are appreciated.  We have had Microsoft on the line and they checked the communications between workstation and server and it appears to be fine, but they do see an error message that they have referred to the Office team.  In the meantime any suggestions are appreciated.

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PITA but try copy the file to desktop, then edit, then save back to server.
JohnBusiness Consultant (Owner)Commented:
I use Office 2016 on my own laptop and also on a Client Workstation I use (both Windows 10 Pro). No issues with saving files on Server 2012 R2.

What is the numerical message of the access denied message?

Are you up to date?  I am at version 16.0.6528.1017. There was a flawed higher version out about 2 weeks ago that Microsoft has withdrawn. The version above is stable and reliable.
Also, for diagnostics, try:
- Open file from server
- Press Alt+F11 to get the VBA IDE
- use View menu to enable 'Immediate Window'
- type:
- Press Enter

Then Do your thing so the error message appears then repeat:
- type:
- Press Enter

to see if the document is ending up in some weird location.
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Peterson50Author Commented:
We have copied file to local workstation hard drive edited it with no issues, then save it back to share and it saves, if we then open and try to edit and save we get the error message, but then something strange happens we close the file as we cannot save it and the file disappears from the share.  Where it goes we do not know it is as if it is deleted.

Will try the other steps mentioned.  These files were copied from another server that they moved from.  We took ownership and applied all permissions again two times.
JohnBusiness Consultant (Owner)Commented:
The other thing you can try is to go back to a prior version (16.0.6366.2068) of Office.  See my article on Outlook 2016 for this fix.

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Alptekin KeskinCIOCommented:
My suggestion would be check the advanced permissions for the file. you can have the permission set to read and write but not to delete plus you can do auditing for the file to figure out who is trying to delete or the reason its not appending the changes.
Alptekin Keskin
@Alptekin... this issue ALSO impacts newly created files, so unlikely that other users are involved, but your mention of DELETE does raise an interesting question - what happens if the user attempts SaveAs?
Thomas KetnerActive Directory Infrastructure/Security ArchitectCommented:
What changes have you made in total?
Do the users which are now using Office 2016
What OS are your users using?
Have a mapped drive to that share?
Has that data been moved or changes to an existing drive letter mapping to the 2012 R2 share?
If a user saves a file to the share, can you log on to the server and see the file?
Do you have offline folders enabled?

This sounds like a classic CSC caching issue. I would post some links, but fixing it depends on the OS and what is different.
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