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Agent or Agent-less for endpoint security, backup & F5 LB

Last Modified: 2016-03-27
Which is better, agent or agentless, in terms of
a) ease of support
b) ease of upgrade/patching
c) stability (as often I've seen agents' status going Offline, Unknown, etc)
d) inteference with apps (have seen agents causing issues to .Net, Java & various apps

For endpoint security (eg: Symantec Endpoint, Trend's Deep Security),
backup (eg: Netbackup, Commvault), and F5 LB?
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