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Exchange 2007 Transport issues

I have Win Server 2008 with Exchange 2007. I have setup a Smarthost on port 587. For years this has been working just fine. However, just today I have this error:

The transport failed to connect to the server.

Of course, no emails are being sent.

Any suggestions? HELP!!!!
ExchangeWindows Server 2008

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8/22/2022 - Mon