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Your text or CSV file does not allow to assign the DNS suffix search order. Best structure would be 

<pre><code class="code-1 nolinks" id="code-20-41712939-1">site,dc
1, DC1
1, DC2
1, DC3
2, DC4
2, DC5
...
</code></pre>
and another one for DNS and suffixes 

<pre><code class="code-1 nolinks" id="code-20-41712939-2">site, DNS, order
1, &quot;172.16.10.12, 172.16.10.13, 172.16.10.14&quot;, &quot;Test.lab, TestB.lab&quot;
...
</code></pre>
Which OS are those DCs running? W8/2012 allows to use some cmdlets, prior OS requires to use e.g. netsh.
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<div>
Running 2008 R2 DC's, 
 
Can you provide detail syntax on the setup of this solution, &nbsp; 
 
Thanks for the reply, &amp;&nbsp;getting back to so soon
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<div>
<div class="content wysiwyg-content">
Need some help 
 
I need to come up with a Powershell script to change multiple Domain Controllers DNS settings. &nbsp; 
 
Please note: Ip address does not need to change, only dns address &amp;&nbsp;dns search order 
 
Sites 1&amp;,2 should have dns address: 172.16.10.12, 172.16.10.13 (search order test.lab, testb.lab) &nbsp; &amp;&nbsp; Site 3 should have 172.16.10.13, 172.16.10.14, 172.16.10.12 (Search order Testb.lab, Test.lab) 
 
DNS Settings: &nbsp;172.16.10.12, 172.16.10.13, 172.16.10.14 &nbsp; &nbsp; &nbsp; 
DNS Search order: &nbsp;Test.lab, TestB.lab 
 
I will like to use either csv(import-csv) or txt(get-content) file will lists all of my DC's. &nbsp; &nbsp;CSV file will likely have columns which lists DNS address, DNS search order, Site Location. 
 
Example 
Test.lab 
Domain controllers, DC1,DC2,DC3,DC4,DC5,DC6 ,DC7,DC8,DC9 
 
Site 1 - DC1,DC2,DC3 
Site 2 - DC4,DC5,DC6 
Site 3 - DC7,DC8,DC9 
 
Please note: The reason I list the sites so that I can organize which DC's will receive DNS settings and DNS search order base on its site location.
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</div>

Need some help

I need to come up with a Powershell script to change multiple Domain Controllers DNS settings.   

Please note: Ip address does not need to change, only dns address & dns search order

Sites 1&,2 should have dns address: 172.16.10.12, 172.16.10.13 (search order test.lab, testb.lab)   &  Site 3 should have 172.16.10.13, 172.16.10.14, 172.16.10.12 (Search order Testb.lab, Test.lab)

DNS Settings:  172.16.10.12, 172.16.10.13, 172.16.10.14       
DNS Search order:  Test.lab, TestB.lab

I will like to use either csv(import-csv) or txt(get-content) file will lists all of my DC's.    CSV file will likely have columns which lists DNS address, DNS search order, Site Location.

Example
Test.lab
Domain controllers, DC1,DC2,DC3,DC4,DC5,DC6 ,DC7,DC8,DC9

Site 1 - DC1,DC2,DC3
Site 2 - DC4,DC5,DC6
Site 3 - DC7,DC8,DC9

Please note: The reason I list the sites so that I can organize which DC's will receive DNS settings and DNS search order base on its site location.

Powershell script to configure DNS setting

Windows PowerShell is a task automation and configuration management framework from Microsoft, consisting of a command-line shell and associated scripting language built on the .NET Framework. PowerShell provides full access to the Component Object Model (COM) and Windows Management Instrumentation (WMI), enabling administrators to perform administrative tasks on both local and remote Windows systems as well as WS-Management and Common Information Model (CIM) enabling management of remote Linux systems and network devices.