Browser link broken for Excel

I have a user who is unable to open .Xlsx files from our SharePoint 2013 Online page. When she clicks on any Excel document (xls or xlsx) in Microsoft edge it gives her the error: "You need a new app to open ms-excel" If she tries to open any file in Internet Explorer it just crashes the browser entirely.

The user is using Windows 10 and Office 2010 Home and Business. I've already tried clearing the settings, resetting the defaults and repairing office.

Any help would be appreciated.
TarkisalAsked:
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TarkisalConnect With a Mentor Author Commented:
Thanks for the response. Oddly, the problem seems to have fixed itself. Microsoft has been pushing out a new site look to individual people in my organization. This particular user had this new look and the "link" to Excel didn't work. However, when she came in this morning, the look had reverted to the old version. I wonder if Microsoft realized it was causing problems and reverted it?

I'm going to leave this ticket open for the rest of the week to see if the problem comes back. If it does, I will try your recommendations.

And to answer your question - The user is running Symantec Cloud, as is everyone else. I tried turning it off but it didn't seem to make a difference.
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Darrell PorterEnterprise Business Process ArchitectCommented:
What, if any, Internet security software is the user running?
Have you tried this with Excel already open on the client system?
Have you already run Powershell as a local admin, CD'd to the root of the user's profile and run
Get-AppXPackage -AllUsers -Name Microsoft.MicrosoftEdge | Foreach {Add-AppxPackage -DisableDevelopmentMode -Register "$($_.InstallLocation)\AppXManifest.xml" -Verbose}

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