So just to recap there is no issue present 100+ datastore to one physical server using SAN Transport mode?
a Dumb Administrator, that logs in, runs Disk Management, says to himself what are all these, and initialises them all and formats them!A really classic human issue you need to avoid. I think in the past I manage to disable the wizard asking for initializing new drives, maybe with diskpart, setting san policy to offlineshared.
2- you mean backup jobs or paths ?!
3- there is no LUN locking here because both will be able to read/write from the LUN, I will also recommend reading your application guidance for SAN transport