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How about IE instead of Edge or Chrome? Not exactly a solution to the problem, but a workaround whilst you troubleshoot further?
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Forgot to mention - I have also uninstalled and reinstalled Chrome.
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Tried IE - it is just too far gone. &nbsp;Lots of other functional problems
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What functionality are you after that Edge / IE can't provide (out of curiosity)?<br />
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If you disable all of your Google Chrome Extensions, how does it behave then?<br />
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How about if you disable all of your Outlook Add-Ins?
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Add-in strip down seems to have no effect.<br />
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Browser tools I have used for years don't work in Edge and IE is now glacial.<br />
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BUT - it takes a day or two for the error to reoccur so testing is a challenge.
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Sorry - ditto on the extensions.
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Thanks very much. &nbsp;I am sure I will get the opportunity to try it.
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I have again stripped Outlook 2016 of all add-ins and then added them progressively back over the last few days. &nbsp;The problem appears to be the Acrobat PDFMaker Office COM Addin which is associated with my Adobe Acrobat XI Pro application. &nbsp;I have deactivated the associated Outlook add-in but can still convert any Outlook emails to pdf via the printing function in Acrobat.<br />
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I can't be certain of this right now, as it has typically taken a long time for the problem to show up, but this looks like the one. <br />
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Thanks very much.
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More information - Adobe says that Acrobat Pro XI is not compatible. &nbsp;Well it worked until very recently. But for only $273 they can fix that problem. Nice!
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Not really - no more functionality for me. &nbsp;I will find something else.
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<div class="content wysiwyg-content">
I am running Outlook 2016 on Windows 10. &nbsp;Chrome is the default browser. &nbsp;All of the applications are up to date.<br />
<br />
When clicking on links embedded in emails in Outlook 2016 I get an error message that the link cannot open. &nbsp;I can make that message go away, and then have the links work, by running a repair on my Office 2016 installation via the Control Panel. &nbsp;BUT within the next day or so the problem returns and I have to do it all again.<br />
<br />
I have gone through the Outlook Add-ins and downsized them considerably. &nbsp; I suspect that there is something in Chrome &nbsp;that causes the problem but I can't nail that down. &nbsp;For now, Edge is inadequate for my needs so I would like to stick with Chrome.<br />
<br />
Any insights would be appreciated.
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I am running Outlook 2016 on Windows 10.  Chrome is the default browser.  All of the applications are up to date.

When clicking on links embedded in emails in Outlook 2016 I get an error message that the link cannot open.  I can make that message go away, and then have the links work, by running a repair on my Office 2016 installation via the Control Panel.  BUT within the next day or so the problem returns and I have to do it all again.

I have gone through the Outlook Add-ins and downsized them considerably.   I suspect that there is something in Chrome  that causes the problem but I can't nail that down.  For now, Edge is inadequate for my needs so I would like to stick with Chrome.

Any insights would be appreciated.

Links to Google Chrome Browser Failing in Outlook 2016

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.

Outlook

Web browsers are applications used primarily to display documents, files and media from the Internet, identified by a Uniform Resource Identifier (URI) that can be a page, image, video or other file. Some browsers require the use of add-ons or extensions to safely render the information they receive; others have systems built into them to perform the same functions.