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XetroximynFlag for United States of America

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deleting HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers

Is deleting HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers OK.... will it effect anything else.  Nuance support just did this on my win10 PC.
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REIT

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Of course this key does not "rebuild" - how should it. When we delete it, application compatibility settings are lost. When we redo those manually, sure, then the values return one by one, but you need to remember what you set before. So deleting without saving it is pretty idiotic. It takes a second to rename it and test and, if not successful, rename it back so you don't lose anything, that is what nuance should recommend and do.
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> So deleting without saving it is pretty idiotic.

Of course, and that's why Nuance says this in (at least some of) the knowledge base articles (copied here under "Fair Use"):
IMPORTANT: This article contains information about editing the registry. Before editing the registry, make sure you understand how to restore it if a problem occurs. Follow the steps below to back up the registry:

1. Open the Registry Editor by clicking "Start > Run". Type in "regedit" without the quotes and click "OK".
2. Export a backup copy of the Registry in case problems occur during the following procedures by clicking "File > Export".
3. Save this file to the Windows Desktop and name the file "backup". (Keep "backup" for a few days and if all is well, this file can be deleted.)
Regards, Joe
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☠ MASQ ☠

Of course this key does not "rebuild" - how should it.
The key HKLM\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers is recreated at reboot if not present - the values aren't