I had a user who was having issues opening Excel .xls files directly from an AS400 network share. It would launch Excel, say that it was downloading the file, get to 100% but then would just stay with a blank Excel window that had everything grayed out and then that would be where it ends. If they take the file and save it to the local disk, it will open just fine, but not when opening from the AS400 share.
I tried a few things I found online, such as disabling WebClient under services.msc, renaming the local Office folder under AppData so that a new one gets rebuilt, but have had no luck thus far.
If anyone has any suggestions, I would appreciate it!