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Outlook Anywhere Issue

I'm having a strange issue with Outlook Anywhere that I can't seem to find the source of the issue.  I'm running Exchange 2010 SP3 RU12 with Outlook 2013.  We have 2 AD sites with 3 CAS Servers in each AD site.  With 2 DAGS spread across the the two sites.  The url setup for everything is mail.domain.com which points to the primary site.  As long as the database is mounted in the primary AD site Outlook Anywhere works flawlessly.  If I fail a database over to the secondary site Outlook Anywhere stops working and the user will receves an error stating "Cannot Start Microsoft Outlook.  Cannot open the Outlook window.  The set of folders cannot be opened.  Network problems are preventing connection to Microsoft Exchange.  Any help would be very much appreciated.
2 Solutions
James EdwardsCommented:
From your description, you have nothing pointing at the secondary site which is where your failover DB is stored and mounted.  So essentially, yes, for all intents and purposes, Exchange is offline and not being able to start Outlook is not surprising.

"The url setup for everything is mail.domain.com which points to the primary site." - so your mail.domain.com, there is a DNS record with your domain name provider, pointing to site A.  You move everything to site B... what then directs everything over to site B?  Presumably Sites A and B are physical different locations and thus have their own IPs?!

I would suggest costed routes with your provider if you are considering a full site-down outage and failover so site B at a higher cost comes in to play when site A goes down.  Or alternatively manually amend records yourself in a DR situation (not preferable).
georgedschneiderAuthor Commented:
I had to disable Outlook anywhere in the secondary site (non internet facing).  This allowed a database failed over to the secondary site to still be accessed.
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