I'm having a strange issue with Outlook Anywhere that I can't seem to find the source of the issue. I'm running Exchange 2010 SP3 RU12 with Outlook 2013. We have 2 AD sites with 3 CAS Servers in each AD site. With 2 DAGS spread across the the two sites. The url setup for everything is mail.domain.com which points to the primary site. As long as the database is mounted in the primary AD site Outlook Anywhere works flawlessly. If I fail a database over to the secondary site Outlook Anywhere stops working and the user will receves an error stating "Cannot Start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened. Network problems are preventing connection to Microsoft Exchange. Any help would be very much appreciated.