Symantec caused Exchange 2013 to stop functioning

We have Exchange 2010 and 2013 SP1 running in the same environment for migration purposes. The server is 2012 R2 and once we installed symantec endpoint protection the migrated mailboxes no longer receive/send emails. After uninstalling SEP the problem is still there. The Exchange transport service will not start. After disabling all the receive connectors the service starts but cannot send mail. During migration the primary exchange (2010) relays mail to 2013 and 2013 relays mail back to 2010 to send. The connection between the two systems seems to be broken.

We have restored an older backup on the 2012 Exchange 2013 server and now the server is at 100% CPU useage. The services are all started but nothing is working.
HodorAsked:
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HodorConnect With a Mentor Author Commented:
Turns out Issue was not related to Symantec. We installed 2013 SP3 because we already owned the software and we don't upgrade to the newest product without sufficient testing in real environments. This helps build a better support community in case issue arise. We ended up connecting Microsoft. Below is their resolution.

Issue Description
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- Unable to send/receive emails getting error "4.7.0 Temporary server error. Please try again later. PRX4" on Exchange 2013 Server [EXCHANGE]
 
Issue Resolution
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- Unable to Inbound proxy from Frontend to Hub Transport as Default Receive Connector's binding was set on Port 2525 & Transport Role was defined as “FrontendTransport” hence changed it to “HubTransport” & issue stands resolved
Related TechNet Article
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Receive connector Exchange 213:  https://technet.microsoft.com/en-us/library/aa996395(v=exchg.160).aspx
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HodorAuthor Commented:
CPU at 100% solved, VM was set to a single processor. We still cannot send or recieve emails on the new exchange
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Eric CIT Director / Project ManagerCommented:
I have no clue how to solve your problem, but I wanted you to know that every time someone holds the door for me, I shed a little tear.
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Todd NelsonSystems EngineerCommented:
Did you set your exclusions so the AV tool doesn't break Exchange?  Also, McAfee used to block port 25 by default unless it was explicitly opened--maybe SEP is doing something similar.

http://exchangeserverpro.com/powershell-script-exchange-2013-antivirus-exclusions/

Personally, I would never recommend AV on an Exchange server with mailboxes.
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Simon Butler (Sembee)ConsultantCommented:
Did you really install Exchange 2013 SP1 and not something more recent?
If not, start by installing the latest cumulative update. Then reboot the machine.

Check if you can actually telnet to port 25 on the server.

As for the Symantec software doing what it does - that doesn't surprise me. Symantec's garbage AV has been providing me with a steady stream of consultancy work for over ten years.
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Dr. KlahnPrincipal Software EngineerCommented:
My experience with Norton Symantec ... I have not yet seen a system that worked right after Norton / Symantec was installed.  These products hook deeply into the system and can never be completely removed even using the Norton Removal Tool.  Usually this manifests by breaking some aspect of networking.

Suggest that you restore the system from the most recent backup prior to installing Symantec, or if this is not possible, try to go back to the Restore Point you created just prior to installing Symantec.
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Eric CIT Director / Project ManagerCommented:
Hodor.
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