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Is there any role of comparative operators or you are concerned only with the number?<br />
Why not post a small sample workbook with desired output mocked up manually?
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Sample.xlsx

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If I have numbers entered as following..<br />
&gt;50<br />
&lt;=100<br />
Excel sees them as text...how can apply conditional formatting so that Excel will highlight the numbers that are greater than 250. Currently I'm thinking there isn't a straightforward way but want to see if I'm wrong :-)
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If I have numbers entered as following..
>50
<=100
Excel sees them as text...how can apply conditional formatting so that Excel will highlight the numbers that are greater than 250. Currently I'm thinking there isn't a straightforward way but want to see if I'm wrong :-)

Conditional formatting for numbers where it's mixed with text...

Microsoft Excel topics include formulas, formatting, VBA macros and user-defined functions, and everything else related to the spreadsheet user interface, including error messages.