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Starting with vSphere 5.0 you can do storage vMotion of virtual machine with snapshots, see: <a href="https://blogs.vmware.com/vsphere/2011/09/storage-vmotion-storage-drs-virtual-machine-snapshots.html" rel="ugc nofollow">https://blogs.vmware.com/vsphere/2011/09/storage-vmotion-storage-drs-virtual-machine-snapshots.html</a>
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No, if done correctly.<br />
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How are you moving it ?
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I wanted to power down the VM and move it, think it's called a &quot;cold VM migration&quot; via the VMware ESXi client&quot; &nbsp;We are running 5.5.0 esxi
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Assuming you are using vCenter, you can do this even with the virtual machine powered on, see: <a href="https://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1035550" rel="ugc nofollow">https://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1035550</a>
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Will I lose snapshots or any configs by moving a VM to another datastore on the host? &nbsp;It's running on Vmware ESXi 5.5.0
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Will I lose snapshots or any configs by moving a VM to another datastore on the host?  It's running on Vmware ESXi 5.5.0

Migrating a VM with Snapshots

VMware, a software company founded in 1998,  was one of the first commercially successful companies to offer x86 virtualization. The storage company EMC purchased VMware in 1994. Dell Technologies acquired EMC in 2016. VMware’s parent company is now Dell Technologies.

VMware has many software products that run on desktops, Microsoft Windows, Linux, and macOS, which allows the virtualizing of the x86 architecture.  Its enterprise software hypervisor for servers, VMware vSphere Hypervisor (ESXi), is a bare-metal hypervisor that runs directly on the server hardware and does not require an additional underlying operating system.

VMware

Windows PowerShell is a task automation and configuration management framework from Microsoft, consisting of a command-line shell and associated scripting language built on the .NET Framework. PowerShell provides full access to the Component Object Model (COM) and Windows Management Instrumentation (WMI), enabling administrators to perform administrative tasks on both local and remote Windows systems as well as WS-Management and Common Information Model (CIM) enabling management of remote Linux systems and network devices.