Google Chrome - your profile could not be opened correctly

I have a client who is getting this message, seemingly out of the blue -

Ah, Snap! Google Chrome - your profile could not be opened correctly. Some features may be unavailable. Please check that the profile exits and you have permission to read and write its contents.

I checked and MBAM had found some PUPs and Trojans earlier this year. Current scans of MBAM are clean. So I did my typical scans. SUPERAntiSpyware (found adware cookies-expected), AdwCleaner (found remnants) , JRT (found remnants), Hitman Pro (found nothing). Ran CCleaner. Uninstalled and re-installed Chrome and still got the error message.

I did extensive search on the issue and did this-

• Ran sfc /scannow - no integrity violations

• Go to google chrome property , go to compatibility Tab and check "run this program in compatibility mode" select win 8 - still did not work

• Created a new browser user profile following Google instructions - Exit Google Chrome completely. Enter the keyboard shortcut Windows key  +E to open Windows Explorer. In the Windows Explorer window that appears enter the following in the address bar. Windows Vista/ Windows 7/ Windows 8/ Windows 10: %LOCALAPPDATA%\Google\Chrome\User Data\ Locate the folder called "Default" in the directory window that opens and rename it as "Backup default." Try opening Google Chrome again. A new "Default" folder is automatically created as you start using the browser. Chrome opened once then stopped working again within minutes

• AVG Toolbar is list as an issue - No toolbar and checked here for remnants - avgtpx64.sys in windows/system32/drivers - not there

• Did a complete removal of Chrome following this instructions -   1. a) First uninstall Google Chrome using the 'uninstall' button in your software panel,  b) And if you see "Google update" uninstall that also;   2. Then restart your computer   3. Go to this folder location If you use Windows7, 8: %LOCALAPPDATA%\Google and delete the folder Chrome, C:\Program Files (x86)\Google\ and delete the folder Chrome, C:\users\YOURNAME\appData\local\temp and delete all the files in this folder;   4. Restart your computer again. (some files are removed if they restart Windows, because Windows is using the files now)   5. Now install Google Chrome - Did not work

• Followed Bleeping Computers instructions for full removal of the Kovter Trojan, Rkill found no virus but some missing items (let me know if you need the report) and Symantec's removal tool found nothing -
• http://www.bleepingcomputer.com/virus-removal/remove-kovter-trojan

• Used Google Chrome's Clean up tool - found no issues

• I turned off Avast's shields - no luck

• I stopped running CCleaner as someone suggested that as an issue which I have never experienced - no luck

• Attempted to start in Safe Mode - I am working remotely with GoToAssist. I never was reconnected. His computer could not access the internet and he could not open Word or Excel. I had him restart his computer and everything worked except for Chrome.

I am at a loss...my concern is that something else is going on. He is using Windows 10 64bit. His Internet security is Avast Premier.
Where do I go from here? Thanks,
Mags