Powershell: Script to run on all DC

If remote PowerShell is enabled on DC's then, you can use Invoke-Command to run commands remotely. But details like what you trying to achieve and the OS on DC's will help you to get a clear answer!
http://ss64.com/ps/invoke-command.html
Example, following code will run Ipconfig /Flushdns command on all DC's

Import-Module Activedirectory
$DCLict = Get-ADDomainController -Filter * | Select -exp name
Invoke-Command -Comp $DCLict { Ipconfig /Flushdns }

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The DC's are running 2008r2.  I need to run a command del c:\temp\*.* on all DC

Does remote PowerShell enabled or can be enabled on all DC's?

Or if admin shares are enabled, then you can try..

Import-Module Activedirectory
Get-ADDomainController -Filter * | %{Remove-Item "\\$($_.Name)\c$\temp\*" -recurse}

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Thanks sub sun. Like the first example you showed, if I want to run multiple commands using invoke-command, how would I modify..

Thanks.  If I want to include a few lines of Powershell script, can I include it in invoke-command section.

Yes you can include it in the script block as I showed in example...

Thanks.