<div>
When you say it has occured on multiple OS versions, did you upgrade the OS or do a fresh install? Or have you done a fresh OS install at some point while you've had the MacBook?
</div>

<div>
Always updated. &nbsp;I've never done a fresh install because I never thought it was necessary like a Windows machine.
</div>

<div>
Typically I'd agree with a Mac but if you've only done upgrades to it the problem could be a software issue that has persisted through the upgrades. As much as I hate to suggest it, the only way to entirely eliminate software as the cause would be to restore it to factory. 
 
You've replaced the only two components I've ever found to be practical to replace in a Macbook, and done the PRAM and SMC resets, other than going into disk utility and running some checks there you've basically performed all the hard ware trouble shooting you can. It wouldn't hurt to start rebooting the machine more often, but I doubt that that is the root cause of this issue.
</div>

<div>
What's that message? You happen to have a screenshot?
</div>

<div>
@Tyler, 
I was afraid of that. 
 
@Gerwin, 
No. :( 
 
I went to Console and looked for 'failure' in the system log queries, but nothing related to what I saw.
</div>

<div>
I never needed a fresh install with a Mac but you may need one after all. 
 
I would format the hard drive before you install / restore from the backup you made before you start.
</div>

<div>
Do you or Tyler have recommendations on kb's I can follow to do something like this?
</div>

<div>
So is your problem that the Mac does not awake from sleep and you have to do a hard shutdown? 
 
Try turning off the hibernate mode with this terminal command: 
 
sudo pmset -a hibernate mode 0 
 
See this link for details: &nbsp;<a href="http://www.markc.me.uk/blog/files/OSXSafeSleep.html" rel="ugc">http://www.markc.me.uk/blog/files/OSXSafeSleep.html</a>
</div>

<div>
I backed up my macbook in Time Machine (I usually do this before I update to another OSX) and updated to Sierra OSX. &nbsp;The same sleep awake failure appears to have happened. &nbsp;This time I grabbed a screenshot. 
 
eg 
 
<a href="https://filedb.experts-exchange.com/incoming/2016/10_w44/1124706/Screen-Shot-2016-10-24-at-8.36.30-PM.png" target="_blank" title="Screen-Shot-2016-10-24-at-8.36.30-PM.png (169 KB)"><img alt="Screen-Shot-2016-10-24-at-8.36.30-PM.png" class="file-block lazyload" style="max-width: 800px;" data-src="https://filedb.experts-exchange.com/incoming/2016/10_w44/800_1124706/Screen-Shot-2016-10-24-at-8.36.30-PM.png" /></a> 
I will look into the other suggestions too, thanks!
</div>

Screen-Shot-2016-10-24-at-8.36.30-PM.png

<div>
I have not had time to try the other suggestions. &nbsp;I will try them when I have time this weekend.
</div>

<div>
Unfortunately the screenshot doesn't tell us anything. Please post the Etrecheck report when you get a chance.
</div>

<div>
<blockquote>
Please post the Etrecheck report when you get a chance.
</blockquote>
Is that from the console? &nbsp;I don't know what that is.
</div>

<div>
<pre><code class="code-100 nolinks" id="code-20-41874854-1">EtreCheck version: 3.1.2 (334)
Report generated 2016-11-04 13:21:53
Download EtreCheck from https://etrecheck.com
Runtime 1:48
Performance: Excellent

Click the [Support] links for help with non-Apple products.
Click the [Details] links for more information about that line.
Click the [Remove] links to remove adware.

Problem: Other problem
Description:
sleep awake failure

Hardware Information: ⓘ
 MacBook Pro (15-inch, Mid 2012) 
 [Technical Specifications] - [User Guide] - [Warranty &amp; Service]
 MacBook Pro - model: MacBookPro9,1
 1 2.3 GHz Intel Core i7 (i7-3615QM) CPU: 4-core
 16 GB RAM Upgradeable - [Instructions]
 BANK 0/DIMM0
 8 GB DDR3 1600 MHz ok
 BANK 1/DIMM0
 8 GB DDR3 1600 MHz ok
 Bluetooth: Good - Handoff/Airdrop2 supported
 Wireless: en1: 802.11 a/b/g/n
 Battery: Health = Normal - Cycle count = 776

Video Information: ⓘ
 Intel HD Graphics 4000
 Color LCD 1440 x 900
 NVIDIA GeForce GT 650M - VRAM: 512 MB

System Software: ⓘ
 macOS Sierra 10.12 (16A323) - Time since boot: less than an hour

Disk Information: ⓘ
 OWC Mercury Electra 6G SSD disk0 : (240.06 GB) (Solid State - TRIM: No)
 [Show SMART report]
 EFI (disk0s1) &lt;not mounted&gt; : 210 MB 
 Recovery HD (disk0s3) &lt;not mounted&gt; [Recovery]: 650 MB 
 OWC (disk1) / [Startup]: 238.83 GB (152.56 GB free)
 Core Storage: disk0s2 239.20 GB Online

 HL-DT-ST DVDRW GS41N ()

USB Information: ⓘ
 Apple Inc. FaceTime HD Camera (Built-in) 
 Apple Inc. Apple Internal Keyboard / Trackpad 
 Apple Computer, Inc. IR Receiver 
 Apple Inc. BRCM20702 Hub 
 Apple Inc. Bluetooth USB Host Controller 

Thunderbolt Information: ⓘ
 Apple Inc. thunderbolt_bus

Gatekeeper: ⓘ
 Mac App Store and identified developers

Adware: ⓘ
 ~/Library/LaunchAgents/com.spigot.ApplicationManager.plist
 1 adware file found. [Remove]

Kernel Extensions: ⓘ
 /Library/Application Support/Avast/components/fileshield/unsigned
 [loaded] com.avast.AvastFileShield (3.0.0 - SDK 10.9 - 2016-09-23) [Support]

 /Library/Application Support/Avast/components/proxy/unsigned
 [loaded] com.avast.PacketForwarder (2.1 - SDK 10.11 - 2016-09-23) [Support]

System Launch Agents: ⓘ
 [not loaded] 7 Apple tasks
 [loaded] 164 Apple tasks
 [running] 100 Apple tasks

System Launch Daemons: ⓘ
 [not loaded] 40 Apple tasks
 [loaded] 158 Apple tasks
 [running] 106 Apple tasks

Launch Agents: ⓘ
 [running] com.avast.secureline.update-agent.plist (2016-10-31) [Support]
 [loaded] com.avast.secureline.userinit.plist (2016-10-31) [Support]
 [running] com.avast.update-agent.plist (2016-09-23) [Support]
 [loaded] com.avast.userinit.plist (2016-09-23) [Support]
 [loaded] com.google.keystone.agent.plist (2016-08-24) [Support]
 [running] org.chromium.chromoting.plist (2016-06-20) [Support]

Launch Daemons: ⓘ
 [loaded] com.adobe.fpsaud.plist (2016-04-15) [Support]
 [loaded] com.avast.init.plist (2016-09-23) [Support]
 [loaded] com.avast.secureline.init.plist (2016-10-31) [Support]
 [loaded] com.avast.secureline.uninstall.plist (2016-10-31) [Support]
 [loaded] com.avast.secureline.update.plist (2016-10-31) [Support]
 [loaded] com.avast.uninstall.plist (2016-09-23) [Support]
 [loaded] com.avast.update.plist (2016-09-23) [Support]
 [loaded] com.bombich.ccchelper.plist (2015-11-04) [Support]
 [loaded] com.google.keystone.daemon.plist (2016-09-02) [Support]
 [loaded] com.paragon-software.camptunex.helper.plist (2016-03-29) [Support]
 [loaded] com.paragon-software.camptunex.installer.plist (2016-03-29) [Support]

User Launch Agents: ⓘ
 [loaded] com.avast.home.userinit.plist (2016-09-23) [Support]
 [loaded] com.avast.secureline.home.userinit.plist (2016-10-31) [Support]
 /usr/bin/open
 [failed] com.spigot.ApplicationManager.plist (2015-11-18) Adware! [Remove]
 [running] com.spotify.webhelper.plist (2016-11-04) [Support]

User Login Items: ⓘ
 iTunesHelper Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
 Canon IJ Network Scanner Selector EX Application Hidden (/Applications/Canon Utilities/IJ Network Scanner Selector EX/Canon IJ Network Scanner Selector EX.app)
 Spotify Application Hidden (/Applications/Spotify.app)

Internet Plug-ins: ⓘ
 Silverlight: 5.1.30214.0 - SDK 10.6 (2015-11-04) [Support]
 FlashPlayer-10.6: 21.0.0.226 - SDK 10.6 (2016-04-21) [Support]
 QuickTime Plugin: 7.7.3 (2016-09-13)
 Flash Player: 21.0.0.226 - SDK 10.6 (2016-04-21) Outdated! Update
 MeetingJoinPlugin: Unknown - SDK 10.6 (2015-11-04) [Support]

Safari Extensions: ⓘ
 Avast Online Security - AVAST Software - http://www.avast.com (2014-10-21)

3rd Party Preference Panes: ⓘ
 remoting_host_prefpane (2016-07-12) [Support]
 Flash Player (2016-04-15) [Support]

Time Machine: ⓘ
 Mobile backups: OFF
 Auto backup: NO - Auto backup turned off
 Volumes being backed up:
 OWC: Disk size: 238.83 GB Disk used: 86.26 GB
 Destinations:
 MBFAT [Local] 
 Total size: 749.81 GB 
 Total number of backups: 8 
 Oldest backup: 12/27/15, 6:46 PM 
 Last backup: 10/22/16, 11:44 AM 
 Size of backup disk: Excellent
 Backup size 749.81 GB &gt; (Disk size 238.83 GB X 3)

Top Processes by CPU: ⓘ
 10% 	kernel_task
 7% 	WindowServer
 6% 	launchd
 5% 	hidd
 2% 	com.avast.proxy

Top Processes by Memory: ⓘ
 1.39 GB 	softwareupdated
 1.01 GB 	kernel_task
 639 MB 	Google Chrome Helper(6)
 557 MB 	mdworker(23)
 246 MB 	Spotify Helper(2)

Virtual Memory Information: ⓘ
 9.33 GB 	Available RAM
 1.66 GB 	Free RAM
 6.67 GB 	Used RAM
 7.67 GB 	Cached files
 0 B 	Swap Used

Diagnostics Information: ⓘ
 Nov 4, 2016, 01:15:54 PM Self test - passed
</code></pre>
</div>

<div>
I don't see anything that specifically points to a cause of your problem, but you do have some Spigot adware that you should remove. You can use the freeware MalwareBytes for Mac to remove it: &nbsp;<a href="https://www.malwarebytes.com/antimalware/mac/" rel="ugc">https://www.malwarebytes.com/antimalware/mac/</a> 
 
Also, I see you are using Spotify and there have been all sorts of reports of problems with it. I would try uninstalling it temporarily to see if that makes a difference. 
 
If the problem continues, perhaps you can post the last 20 or so lines in Console immediately before the restart after the crash.
</div>

<div>
<blockquote>
Spigot adware that you should remove.
</blockquote>
Done. &nbsp;Thanks for that.
</div>

<div>
Spotify is removed. 
 

<blockquote>
If the problem continues, perhaps you can post the last 20 or so lines in Console immediately before the restart after the crash.
</blockquote>
I will try to get this.
</div>

<div>
OK I uninstalled it for now. &nbsp;Will report back my findings.
</div>

<div>
After several days, the problem has not been exhibited. &nbsp;Removing Avast appears to have been the Best Solution. &nbsp;Thanks for the additional assisted solutions too!
</div>

<div>
All, 
 
Unfortunately, there is still a problem. &nbsp;Your help is appreciated. &nbsp;I have asked a new question based off this one. 
<a href="https://www.experts-exchange.com/questions/28994647/Macbook-has-frequent-sleep-awake-failures-part-2-status-0x40003-Code-0x100002000014-Stackshot-reason-Watchdog.html" rel="ugc nofollow">https://www.experts-exchange.com/questions/28994647/Macbook-has-frequent-sleep-awake-failures-part-2-status-0x40003-Code-0x100002000014-Stackshot-reason-Watchdog.html</a>
</div>

<div>
<div class="content wysiwyg-content">
Macbook Pro 
15-inch, Mid 2012 
OS X El Capitan 
Processor 2.3GHz Intel Core i7 
Memory 16GB 
Graphics Intel HD Graphics 4000 1024 MB 
240GB &nbsp;SSD 
 
Anyone know why this happens? &nbsp; 
How can I prevent this from happening? 
 
I have tried PRAM and SMC resets in the past. 
This has happened on multiple OSX versions: Mountain Lion, Mavericks, Yosemite and El Capitan. &nbsp;I'm assuming this has to be more of a hardware failure than software. &nbsp;In the time that I have owned this macbook I have replaced the memory and hard drive. &nbsp;I hardly ever restart the machine. &nbsp;I usually have 10 tasks open all the time. 
 
After it happens I get a message that asks if I want to ignore the problem or send to Apple. &nbsp;I send to Apple.
</div>
</div>

Macbook Pro
15-inch, Mid 2012
OS X El Capitan 
Processor 2.3GHz Intel Core i7
Memory 16GB
Graphics Intel HD Graphics 4000 1024 MB
240GB  SSD

Anyone know why this happens?  
How can I prevent this from happening?

I have tried PRAM and SMC resets in the past.
This has happened on multiple OSX versions: Mountain Lion, Mavericks, Yosemite and El Capitan.  I'm assuming this has to be more of a hardware failure than software.  In the time that I have owned this macbook I have replaced the memory and hard drive.  I hardly ever restart the machine.  I usually have 10 tasks open all the time.

After it happens I get a message that asks if I want to ignore the problem or send to Apple.  I send to Apple.

Macbook has frequent sleep / awake failures

All of Apple's hardware is produced solely by Apple Inc., who determines internal systems, designs, and prices. Apple buys certain components wholesale from third-party manufacturers. The current Mac product family uses Intel x86-64 processors. All Mac models ship with at least 1 GB RAM as standard. Current Mac computers use ATI Radeon or nVidia GeForce graphics cards and include a dual-function DVD and CD burner, called the SuperDrive. Current Apple hardware includes the iPad, iPhone, iMac, Mac Pro, Macbook, iPod and Apple TV. Discontinued hardware includes the Apple I, Apple II, and the Apple III, the Lisa, the Newton, the Quadra, Performa, Centris, Macintosh II and LC series, the Power Macintosh, iBooks and the MacBook.

Apple Hardware

Apple's early computers ran on a variety of operating systems, including a Pascal version and one based on CP/M, before releasing its ProDOS with the advent of its 16-bit computer. With the release of the Lisa, which had its own OS, Apple and computing entered the graphical age; it was followed by the Macintosh, which offered a series of "System" operating systems. Other Mac operating systems included PowerPC until Apple acquired NeXT and folded it into the Mac OS. Current operating systems for Apple devices are Mac OS-X and iOS.

Apple OS

Mac OS X is the desktop operating system from Apple Inc., found on Macintosh computers. OS X consists of a Mach/BSD-based kernel, operating system interfaces primarily based on FreeBSD and additional frameworks (written in C, C++ and Objective-C providing user interface and application-level services.

Mac OS X

Hardware includes cell phones and other digital living devices, tablets, computers, servers, peripherals and components, printers and scanners, gaming consoles, networking hardware such as routers, hubs, switches and modems, storage devices and security equipment such as firewalls and other appliances.

Hardware

A laptop or notebook is a portable personal computer with a clamshell form factor, suitable for mobile use. Although originally there was a distinction between laptops and notebooks, the former being bigger and heavier than the latter, there is often no longer any difference. Laptops are commonly used in a variety of settings, such as at work, in education, and for personal multimedia. A laptop combines the components, inputs, outputs and capabilities of a desktop computer, including the display screen, speakers, a keyboard, and pointing devices (such as a touchpad or trackpad) into a single unit. The device can be powered either from a rechargeable battery or by mains electricity from an AC adapter.