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PrefMara

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Exchnage 2013 Error '550 5.7.1 Requested action not taken: message refused'

Started getting the 5.7.1  error along with "Your message wasn't delivered due to a permission or security issue. It may have been rejected by a moderator, the address may only accept email from certain senders, or another restriction may be preventing delivery." and the refusing server is our front end Exchange 2013 server. This happens when users send an email to a single domain outside our org.
This just started happening and we have been sending to that domain for years.

We are using Symantec Mail Security and their tech's say it's the Exchange server and not their software that is rejecting the message.
All the Exchange Agents except Address Rewriting, Edge Rule,Attachment Filtering and Address Rewriting are disabled on the front end server so I'm not sure whats preventing the delivery of the email. Any ideas where to start looking would be appreciated. Thanks.
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btan

To add some checks

Under the exchange system manager, go to
> Servers> then protocols> smtp> and properties of the default SMTP virtual server. Go to the access tab and verify that your certificate is installed for secure communication.

Check the logs on your GW filters, Antispam filters and check your exchange content filters
e.g. for filters > Global Settings > Message Delivery (right click > Properties) > Intelligent Message Filtering then check the "When blocking messages", check if it is set to No Action and if not, set it and see if error still occurs.  If that helps, it means the threshold need to be set higher.
Is this a external to internal or internal to internal email?
The mail is to distribution list? It is look like mail to distribution which by default mail to distribution from external will be rejected due to require authentication. If

If mail from internal to distribution and it can a failed, there is settings whereby only list of users who allow to send an email to distribution
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I ran the command successfully on the HUB server but I'm getting "The operation couldn't be performed because object PM**** couldn't be found on'localhost' when I try and run it on the Edge server.
It's a Internal to External email. No distribution list involved.
Does it happened to all user when they try to send an email to this problematic external domain? Try run message tracking to see what error show.