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I do not think so. Cached mode CREATES an OST file so it can do its job.
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I do not think so. Cached mode CREATES an OST file so it can do its job.

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I've discovered if you leave the settings for it not configured in the GPO it creates the profile in cached mode by default.<br />
The only way I've been able to get it to not do so is to configure it to disabled. &nbsp;This prevents the user from being able to then check the box and start using cached mode at a later time.<br />
What is needed is for it to be created in Online mode but with the user to have the ability to choose cached mode later.
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I've discovered if you leave the settings for it not configured in the GPO it creates the profile in cached mode by default.
The only way I've been able to get it to not do so is to configure it to disabled.  This prevents the user from being able to then check the box and start using cached mode at a later time.
What is needed is for it to be created in Online mode but with the user to have the ability to choose cached mode later.

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That's what I was afraid of.
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Following article will help you to To Disable OST files and switch cached exchange mode off using registry. <br />
<br />
<a href="http://www.edwardsd.co.uk/work/2013/05/outlook-2010-enabledisable-cached-exchange-mode-via-regedit/" rel="ugc">http://www.edwardsd.co.uk/work/2013/05/outlook-2010-enabledisable-cached-exchange-mode-via-regedit/</a><br />
<br />
<a href="http://www.bytemedev.com/powershell-disable-cached-mode-in-outlook-20102013/" rel="ugc">http://www.bytemedev.com/powershell-disable-cached-mode-in-outlook-20102013/</a>
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Following article will help you to To Disable OST files and switch cached exchange mode off using registry.

http://www.edwardsd.co.uk/work/2013/05/outlook-2010-enabledisable-cached-exchange-mode-via-regedit/ [http://www.edwardsd.co.uk/work/2013/05/outlook-2010-enabledisable-cached-exchange-mode-via-regedit/]

http://www.bytemedev.com/powershell-disable-cached-mode-in-outlook-20102013/ [http://www.bytemedev.com/powershell-disable-cached-mode-in-outlook-20102013/]

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Thank you Steven, and I was happy to work with you on this issue
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Thank you Steven, and I was happy to work with you on this issue

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Is there a way to force Outlook 2016 to create a new profile in Online mode, without creating an OST file, &nbsp;but not with Cached mode disabled?<br />
Thus leaving the &quot;Use Cached Exchange Mode&quot; box unchecked but not grayed out.
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Is there a way to force Outlook 2016 to create a new profile in Online mode, without creating an OST file,  but not with Cached mode disabled?
Thus leaving the "Use Cached Exchange Mode" box unchecked but not grayed out.

Outlook 2016 Profiles

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.