Recently, this system became very slow. Mouse clicks don't seem to happen ... but the result shows up later. Browser tabs don't open right away. Boot process at the point that Desktop is populatiing is very slow. etc.
It runs OK in safe mode.
It runs OK in Knoppix
HDTune shows HD transfer speeds are normal.
Task manager doesn't show anything interesting.
Malwarebytes 3.06 finds nothing.
32 bit system with 3GB RAM has always been fine.
Disk Usage at 100%
Disabled Service: Connected User Experiences and Telemetry which refers in the Services list to Service name: Diag Track.
Had a similar situation with a somewhat better computer not responding the remote access mouse clicks.
Did the same thing. It helped a LOT!!