Exchange 2013 CU16 and later require .NET Framework 4.6.2. Upgrade your servers to .NET Framework 4.6.2 before you install Exchange 2013 CU16 or you'll receive an error. If .NET Framework 4.5.2 is installed on your Exchange servers, upgrade your servers to Exchange 2013 CU15 before installing .NET Framework 4.6.2.
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