Windows 2012 R2 - Remote Desktop Server - best way to create new profile.

Hello,

We are running a Windows 2012 R2 Remote Desktop Server in a Windows 2012 Domain.

I have suspicion that some of the various problems I am seeing are stemming from problematic profiles.  I would like to create fresh profiles for these users.

What is the correct recommended way to do so - create a new profile on Remote Desktop Server?

Thanks in advance.

Regards,
Real-Timer