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Yes, depends on the other free resources you have available.<br />
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and do you really require 16 sockets for your VM.
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I have a cluster of 3 esxi hosts, each host has 2 x 8-core CPU and 256GB RAM; datastore size 6TB.<br />
Is it realistic to run a MS SQL server VM with 16 core, 128GB RAM, and 3TB disk space on this cluster?
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I have a cluster of 3 esxi hosts, each host has 2 x 8-core CPU and 256GB RAM; datastore size 6TB.
Is it realistic to run a MS SQL server VM with 16 core, 128GB RAM, and 3TB disk space on this cluster?

Yes, depends on the other free resources you have available.

and do you really require 16 sockets for your VM.

VM sizing

VMware, a software company founded in 1998,  was one of the first commercially successful companies to offer x86 virtualization. The storage company EMC purchased VMware in 1994. Dell Technologies acquired EMC in 2016. VMware’s parent company is now Dell Technologies.

VMware has many software products that run on desktops, Microsoft Windows, Linux, and macOS, which allows the virtualizing of the x86 architecture.  Its enterprise software hypervisor for servers, VMware vSphere Hypervisor (ESXi), is a bare-metal hypervisor that runs directly on the server hardware and does not require an additional underlying operating system.