Exchange 2007 Outlook 2010

Hi, in our environment we don't have autodiscover and Outlook 2010 connects directly to an exchange 2007 server.  We are introducing an Exchange 2013 server to be a Hybrid server to migrate mailboxes to Office 365. We are adding autodiscover internally and externally to point to mail.domain.com which is our OWA. How will this affect Outlook clients once we modify the existing Autodiscover URI which currently points to servername.domain.local to mail.domain.com. Will all Outlook profiles need to be reconfigured?

Clients are all Outlook 2010, Exchange server is 2007

TIA