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Better malware protection

Hello Experts - I am looking for a way to better protect my company from the cryptovirus malware that seems to be everywhere these days.  I have a basic level of security with a Barracuda email filter, TrendMicro antivirus, and websense web filtering but stuff still gets through all the time and despite nearly weekly emails imploring people not to open questionable emails, they still do.  We've been hit twice in the past with cryptoviruses which I was fortunately able to catch early thanks to a canary on the file server looking for signature files.  I also have good backups but I'd really prefer not to use them and instead do more to prevent these things from causing problems in the first place.

In addition to the basics that I have setup now, what other services or techniques can I check out that will help protect my data from this malware?  I'd very much appreciate any advice, thanks!
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John
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Ok, making me feel a little better.  :)  I do have solid, offsite backups and we do Windows updates once a week including the servers.  I blasted out yet another "please for the love of God don't open bad attachment" emails this morning.
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Agreed, local users do not have admin rights and we've done a ton of education.  The problem I see is that there is a certain percentage of the group that are what I call willfully ignorant.  It's ironic because the staff I am working with are generally smart people, engineers and the like. But when it comes to computers they develop this attitude where its all just beyond them and they can't figure out even basic things like not clicking on an obviously suspect link embedded in a PDF attachment.  So I have to assume that there is always going to be a small percentage of the group who will click that attachment.
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I'm looking at excluding executables from the temp folders but I need to test that pretty thoroughly first, we have lots of plugins and applications and that is bound to cause trouble with some of them.  I'm using web filtering with both my firewall and websense to prevent the obvious bad domains.
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Thanks and I was happy to help