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If nothing has changed in the configuration recently I would check the status off the application pool on the server that is not communicating.
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If nothing has changed in the configuration recently I would check the status off the application pool on the server that is not communicating.

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no configuration changes are done in primary server, only secondary server is moved to Xen Server cluster, after that link issue coming with primary server.
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no configuration changes are done in primary server, only secondary server is moved to Xen Server cluster, after that link issue coming with primary server.

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if the iis app pools are fine and running I would check the rcmctrl.log for errors.
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if the iis app pools are fine and running I would check the rcmctrl.log for errors.

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there is no error found in rcmctrl.log in primary and secondary site both.
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there is no error found in rcmctrl.log in primary and secondary site both.

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I'm out of ideas myself but have you checked this one it is also related to replication failure. <br />
<a href="https://www.experts-exchange.com/questions/28673696/SCCM-2012-R2-Site-Replication-Failing.html" rel="ugc">https://www.experts-exchange.com/questions/28673696/SCCM-2012-R2-Site-Replication-Failing.html</a>
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I'm out of ideas myself but have you checked this one it is also related to replication failure.
https://www.experts-exchange.com/questions/28673696/SCCM-2012-R2-Site-Replication-Failing.html [https://www.experts-exchange.com/questions/28673696/SCCM-2012-R2-Site-Replication-Failing.html]

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<div class="content wysiwyg-content">
HI Team, <br />
<br />
one link from primary to secondary site is failed. I tried to troubleshoot with few logs and replication analyzer tool but not sure how to resolve it. Please help, please find attached error details. Please provide few hint or suggestion, thanks.<br />
<a href="https://filedb.experts-exchange.com/incoming/2017/09_w37/1192672/Linkfailure.docx" target="_blank" class="file-inline" title="SCCM Link failure (120 KB)"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path d="M67.508 468.467c-58.005-58.013-58.016-151.92 0-209.943l225.011-225.04c44.643-44.645 117.279-44.645 161.92 0 44.743 44.749 44.753 117.186 0 161.944l-189.465 189.49c-31.41 31.413-82.518 31.412-113.926.001-31.479-31.482-31.49-82.453 0-113.944L311.51 110.491c4.687-4.687 12.286-4.687 16.972 0l16.967 16.971c4.685 4.686 4.685 12.283 0 16.969L184.983 304.917c-12.724 12.724-12.73 33.328 0 46.058 12.696 12.697 33.356 12.699 46.054-.001l189.465-189.489c25.987-25.989 25.994-68.06.001-94.056-25.931-25.934-68.119-25.932-94.049 0l-225.01 225.039c-39.249 39.252-39.258 102.795-.001 142.057 39.285 39.29 102.885 39.287 142.162-.028A739446.174 739446.174 0 0 1 439.497 238.49c4.686-4.687 12.282-4.684 16.969.004l16.967 16.971c4.685 4.686 4.689 12.279.004 16.965a755654.128 755654.128 0 0 0-195.881 195.996c-58.034 58.092-152.004 58.093-210.048.041z"/></svg>Linkfailure.docx</a>
</div>
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Linkfailure.docx

HI Team, 

one link from primary to secondary site is failed. I tried to troubleshoot with few logs and replication analyzer tool but not sure how to resolve it. Please help, please find attached error details. Please provide few hint or suggestion, thanks.

SCCM Link Failure

Systems Center Configuration Manager (SCCM, formerly known as Systems Management Server) is Microsoft’s system software for managing large groups of not only Microsoft computers, but those running other operating systems, such as Linux, OS-X, and various mobile technologies.