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RStudio Shiiny and linux servers

The R program that we have calls other proteomics open source software installed in the user PCs.  I am going to install RStudio server and the Sniny server in linux so that everyone can access the program remotely.  The idea is to keep the proteomics software in the user PCS and just install the R program in the server.  Is this possible? Will the server be able to locate the software installed in the user PCs?
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Pavel Celba
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Would you recommend to install the open source applications in the linux server as well?
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The R open source I am using is single threaded, and I do not if the open source programs are single threaded or multi threaded for concurrent use by many users.  From the R perspective I do not see any problem because the R program will respond to requests serially.  If the other programs are single threaded and they are called by users remotely while the R program is calling them at the same time, will there be any issues?  Is there any configuration that one can create in the server so there is safe concurrent access to the programs?
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Thanks!
Author expressed thanks without question closing so I've completed this less important step :-).