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best would be Move the Mail.Queue database to a separate drive.<br />
<br />
<a href="https://technet.microsoft.com/en-us/library/bb125177%28v=exchg.150%29.aspx?f=255&MSPPError=-2147217396" rel="ugc">https://technet.microsoft.com/en-us/library/bb125177%28v=exchg.150%29.aspx?f=255&MSPPError=-2147217396</a>
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I do not want to change the mail.queue location. <br />
<br />
I want to stop its increasing size. Generally if mail is processed, it should automatically get release from Mail.queue but I think either this is not happening or happening very late. I need your support to fix large size 14 GB of mail.queuque
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I am using exchange 2016, its Mail.queue is located on C drive it is continously increasing due to which some times fail flow stopped and after restarting exchange services, it works. Current size is more than 14 GB. I have some of client who are using exchange 2010 and exchange 13, their mail.queue never increase while they have many mailboxes than this. I decreased Safety net time and other thing but stilll increasing. I followed below links. <br />
<br />
Every time, Recreating Mail.queue is not possible for.<br />
<br />
<a href="http://www.admin-enclave.com/en/articles/exchange/296-resolved-exchange-hub-transport-mail-que-file-large-in-size.html" rel="ugc">http://www.admin-enclave.com/en/articles/exchange/296-resolved-exchange-hub-transport-mail-que-file-large-in-size.html</a>&nbsp;<br />
<br />
<a href="https://social.technet.microsoft.com/Forums/ie/en-US/c896f0fe-e5ba-4138-92e8-8ce657144112/mailque-file-size-is-rapidly-increasing?forum=exchangesvradmin" rel="ugc nofollow">https://social.technet.microsoft.com/Forums/ie/en-US/c896f0fe-e5ba-4138-92e8-8ce657144112/mailque-file-size-is-rapidly-increasing?forum=exchangesvradmin</a>
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I am using exchange 2016, its Mail.queue is located on C drive it is continously increasing due to which some times fail flow stopped and after restarting exchange services, it works. Current size is more than 14 GB. I have some of client who are using exchange 2010 and exchange 13, their mail.queue never increase while they have many mailboxes than this. I decreased Safety net time and other thing but stilll increasing. I followed below links. 

Every time, Recreating Mail.queue is not possible for.

http://www.admin-enclave.com/en/articles/exchange/296-resolved-exchange-hub-transport-mail-que-file-large-in-size.html 

https://social.technet.microsoft.com/Forums/ie/en-US/c896f0fe-e5ba-4138-92e8-8ce657144112/mailque-file-size-is-rapidly-increasing?forum=exchangesvradmin

Mail.queue DB file is increasing continuously

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.