Cannot access a website I know is online

We have a web-based database front-end that we can access over the public internet (i.e. outside our network) (address is along these lines -  Up until this past week, we could access it via any browser.  Now, however, I can't access it from my home network (laptop and PC) through any Chrome - the browser in which this app works best.  I can access it using IE and Firefox.

Chrome returns this message (also attached):
    This site can't be reached
    The connection was reset.

Oddly, though, I can access it with Chrome when browsing Incognito.    I've searched through all settings and can't figure out which one might affect something like this.  

Any suggestions?
Who is Participating?
Jayadev NairApplication DeveloperCommented:
Since IE and firefox can hit the application, application side is good. Chrome has few security settings/features of its own. Since incognito helps, which means some of your locally identifying information is the issue. Did you try clearing local history and cookies?

  1. On your computer, open Chrome.
  2. On your browser toolbar, click More Moreand then More Tools and then Clear Browsing Data.
  3. In the "Clear browsing data" box, click the checkboxes for Cookies and other site data and Cached images and files.
  4. Use the menu at the top to select the amount of data that you want to delete. Choose beginning of time to delete everything. Note: This option does not appear on all devices.
  5. Click Clear browsing data.
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