sugarcrm application issue due to mysql performance

Dear Experts

We are having SugarCRM enterprise with good hardware very frequently users are getting httpd 500 server error this happens to all users at the same time, once restart the mysql server then works for some time like 30 mins to one hour approx and again the same issue httpd 500 server error just before this occurs very slow experience and then finally ends up with httpd 500 server error,  some times if users reload it works some times I have to restart the mysql service, I am running mysql 5.6.
my.cnf below posted
/etc/opt/rh/rh-mysql56/my.cnf
#
# This group is read both both by the client and the server
# use it for options that affect everything
#
[client-server]

#
# This group is read by the server
#
[mysqld]
# Disabling symbolic-links is recommended to prevent assorted security risks
symbolic-links=0

#
#
#[mysqld]
max_connections=5000
# include all files from the config directory
#
!includedir /etc/opt/rh/rh-mysql56/my.cnf.d
-----------------------------------------------------------------------------------------------end--------------
just added max_connections=5000 as mentioned above but not sure this will resolve can you please suggest best practice performance steps setting up for mysql server , thanks in advance