How to enable\Disable domain users Application in PC's to connect SQL Server 2008 r2

I have some PCs have APP connect to SQl server
How to enable\Disable this APP to connect  SQL Server 2008 r2 for some "Domain users's"
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Hani M .S. Al-habshiContributor as IT ExpertAsked:
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als315Commented:
Go to SQL Management Studio and assign proper rights for your database. Usually we use groups in active Directory. You can assign users to group with rights to access SQL data and they will have access. Other ones will have no access
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EugeneZ ZhitomirskySQL SERVER EXPERTCommented:
if your users have sql login
you can do this by using this command

ALTER LOGIN youruserlogin DISABLE
ALTER LOGIN youruserlogin ENABLE

more
https://docs.microsoft.com/en-us/sql/t-sql/statements/alter-login-transact-sql
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Hani M .S. Al-habshiContributor as IT ExpertAuthor Commented:
1-Application connect to SQL server ?
2-this Application installed on uses PC's ?
how i prevent this application to connect to SQl server from any user PC ?
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als315Commented:
How this application connects to SQL server? With stored account?
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EugeneZ ZhitomirskySQL SERVER EXPERTCommented:
you can set your sql server firewall to restrict  to just approved Servers\PC access

more
Configure the Windows Firewall to Allow SQL Server Access
https://docs.microsoft.com/en-us/sql/sql-server/install/configure-the-windows-firewall-to-allow-sql-server-access
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