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If they copy the file to their C: drive, can they open it then?<br />
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If not: 1. Run Excel in safe mode (run &quot;excel /safe&quot;)<br />
2. Rather than a repair of office, I recommend a complete uninstall and reinstall, then reapply patches.
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If they copy the file to their C: drive, can they open it then?

If not: 1. Run Excel in safe mode (run "excel /safe")
2. Rather than a repair of office, I recommend a complete uninstall and reinstall, then reapply patches.

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Good find. Thanks for getting back with the results.
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Good find. Thanks for getting back with the results.

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Stumbled across cause and solution after posting
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Stumbled across cause and solution after posting

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One user cannot open a saved excel xlsx file. Other users can. And the user can open other excel files. Wet to backup files before problem, still cannot open, other users can. Error popup box says Could not open 'G:\2018 accounting worksheets\dailycheckbook 2018.xlsx' &nbsp;and in blue small type WAS THIS INFORMATION HELPFUL? &nbsp; &nbsp;Repaired office 2010, File security . &nbsp;to recap, 1 user cannot open 1 file, the spreadsheet only has 8 lines and 10 columns and 1 link to last years ending total. Other people can open the file and it works correctly, the user can open other spreadsheets. All users are using the same version excel. 2010. The Backup copy and 2 days prior get the same message. &nbsp;deleted the link, and the problem continued. Rebooted, same issue.
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One user cannot open a saved excel xlsx file. Other users can. And the user can open other excel files. Wet to backup files before problem, still cannot open, other users can. Error popup box says Could not open 'G:\2018 accounting worksheets\dailycheckbook 2018.xlsx'  and in blue small type WAS THIS INFORMATION HELPFUL?    Repaired office 2010, File security .  to recap, 1 user cannot open 1 file, the spreadsheet only has 8 lines and 10 columns and 1 link to last years ending total. Other people can open the file and it works correctly, the user can open other spreadsheets. All users are using the same version excel. 2010. The Backup copy and 2 days prior get the same message.  deleted the link, and the problem continued. Rebooted, same issue.

excel 2010 Cannot open xlsx file after save other users can open

Microsoft Office is an integrated suite of applications that includes Outlook, Word, Excel, Access, PowerPoint, Visio and InfoPath, along with a number of tools to assist in making the individual components work together. Coding within and between the projects is done in Visual Basic for Applications, known as VBA.

Microsoft Office

A spreadsheet is an interactive computer application program for organization, analysis and storage of data in tabular form. Spreadsheets developed as computerized simulations of paper accounting worksheets. The program operates on data represented as cells of an array, organized in rows and columns. Each cell of the array may contain either numeric or text data, or the results of formulas that automatically calculate and display a value based on the contents of other cells.

Spreadsheets

Security is the protection of information systems from theft or damage to the hardware, the software, and the information on them, as well as from disruption or misdirection of the services they provide. The main goal of security is protecting assets, and an asset is anything of value and worthy of protection.  Information Security is a discipline of protecting information assets from threats through safeguards to achieve the objectives of confidentiality, integrity, and availability or CIA for short. On the other hand, disclosure, alteration, and disruption (DAD) compromise the security objectives.