Trouble with USB HD adapters reading gpt formatted drives

I back up my network monthly to a 3 to 4TB HD, and store the drive. I have been using usb 2.0/3.0 SATA adapters for this for almost ten years.  I probably have a dozen or more of these adapters, some originally bought back when I was only using 1-2 TB drives.  
Recently, it seems that many of these devices cannot read/access these bigger drives: I format the drive to max (3-4 TB), write the data, verify that the data can be read, and store the drive.  
However, putting a drive in a different device, it won't read the data, or even recognize the drive.  In Disk Management, it appears only to recognize an "2048GB Healthy (GPT Protective Partition)", and a "1678GB Unallocated" one.  In other words, it seems to be unable to recognize the actual GPT format of the drive.  Some of the drives will never recognize the GPT; some do occasionally; some will if attached to a USB 2 port, but not a USB 3.  Many work part of the time.
Usually, I can remount the drive in the original toaster and read the data, but there have been a few instances where I could not even get that to work.  So far, I have always been able to find a device that eventually would read the data, but this is a troubling trend.
I can't seem to find any discussion of this.
Servers: MS Server 2012R2 (same problem with 2008R2); Windows 7 & 10.  USB adapters from Rosewill, Masscool, IcyDock, StarTech, Orico, Thermaltake, etc.
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Dr. KlahnPrincipal Software EngineerCommented:
I haven't run into this personally.

However, if you're doing a lot of this you might be better off with eSATA.  It is genuine SATA which would eliminate any USB-SATA adapter issues.  It also eliminates the issue of flaky USB 2.0 and 3.0 connections.
Mal OsborneAlpha GeekCommented:
The problem is probably the sector size. Older drives under 2Tb in capacity tended to use 512byte sectors, while newer, larger drives tend to use 4K ones. There are quite a few compatibility issues, Also, some USB drives power down and not wake up quick enough.

Here is some more info and a list of tested and working drive models:
noxchoGlobal Support CoordinatorCommented:
You cannot use these adapters with drives over 2TB. It is a known issues and was detected with first 2.5TB drives. As far as I know there is no solution for this problem as the issues is caused by the driver located on the logical board of these adapters.
The only solution I've yet seen is getting newer boxes which claim to support 2TB+ drives.

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noxchoGlobal Support CoordinatorCommented:
Daniel, any comment on this question?
Seth SimmonsSr. Systems AdministratorCommented:
No comment has been added to this question in more than 21 days, so it is now classified as abandoned.

I have recommended this question be closed as follows:

-- noxcho (https:#a42437249)
-- Mal Osborne (https:#a42436926)

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