Unresponsive applications with macOS High Sierra

Unresponsive Applications

I have Mac Mini running *Very* slowly - CleanMyMac3 consistently reports "Unresponsive Applications"

For example:
starting Google Chrome with 6 pages takes 56 Sec.
Start macOS from powerup takes 4.5 minutes

LaunchPad count is 104 Applications.  

About this Mac reports:

Mac Mini (Mid 2011), 8 GB 1333 Mhz DDR3 RAM, macOS 10.13.2

System Information reports:

Macintosh HD 130.23 GB of 499.25 GB available

About 25% of the Apps can be temporarily deactivated -  (Move to another storage folder - Folder Name, i.e. Inactive Applications?)
Many data files can be stored in iCloud & local backup & recalled for use.

How best to speed up system response?
Who is Participating?
Eoin OSullivanConsultantCommented:
CleanMyMac3 is a load of rubbish - I'd not use it as any indication of the state of a Mac

Number of apps in LaunchPad has no effect on performance so forget about that

2011 Mac Mini is definitely a clue/issue that is a 7 year old device and even with 8GB RAM is going to struggle a bit with the latest OSX version.

iCloud and storing files in backup is not a performance issue.

I'd look at Activity Monitor, all your applications in Startup, What applications and processes are running all the time
MARSPATHAuthor Commented:
Thanks for your input

'tis as I expected - CPU slow with High Sierra.

Looking into latest Mac Mini...
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