Brand New Windows 10 PC. Had Outlook 2013 but when I would goto file, options, signature the window never opened. I repaired, uninstalled, installed 2016, checked for updates etc. I removed mail profile, manually removed app data files etc.
Still the Signature button does not work. It is not grayed out... it just freezes for a minute then does nothing. I ran in safe mode, disabled antivirus as well.
Regedit the following keys:
Change both (Default) and LocalServer32 values in each to C:\Program Files (x86)\Microsoft Office\Office14\Outlook.ex