We have deployed a few Office 2016 Standard installs and we are seeing some very strange issues. If you leave Outlook open for an hour or longer it will freeze up or the screen will go black when you go to access it. If you wait long enough it will come back, during that time a bubble will pop up in the lower right corner of Outlook telling you "trying to connect to CAS". Also, often and hard to reproduce is if you try to access the Address book you will get an error telling you it can't access the address book. You close the error and try again it will open or you may have to close it a couple of times.
We have an on prem exchange 2010 server and 2013 and 2016 clients, no 365. We also use auto-discovery and it seem to me setup correctly don't get any errors about that. I say it seem fine because when we went to Exchange 2010 Microsoft did the install and setup.
We are lost, any help or direction would be greatly appreciated.