Make sure that GPO is linked to the correct OU and an OU contains all objects + that GPO is not enforced, no Block inheritance is set or no security filtering or WMI filtering is applied.

To apply your GPO:
GPO Computer Configuration
- wait up to 120 mins
OR gpupdate/force + reboot
OR just reboot

GPO User configuration
- wait up to 120 mins
OR gpupdate/force + log off and log in
OR log off and log in at least twice

Where do you run rsop.msc and gpresult, both at the client, I hope. gpresult needs to be run on an elevated command prompt, if you are investigating computer policies. So right click cmd.exe and select "run as administrator" and then run gpresult.

If you run gpresult /r at command prompt you will only see user settings.  If you have no user defined GPOs then Applied GPOs will show NA

Run command prompt as administrator and then run gpresult /r and you'll see the computer settings and user settings.  You'll then see the computer applied GPOs.

Add read permission to domain computers on the GPO

The weird thing is if i run rsop, i see the settings in there and also from the correct gpo.
And the settings are definitly applied to the computer. I tested the affected configuration changes.

I tried running cmd as admin but still cant see it.

Where do you run rsop?
Did you run gpresult elevated?

I asked before, please include me in your feedback.

I ran rsop on the client where the policies are applied and yes i ran gpresult elevated

rsop shows the policies, gpresult not? Can you prove that with a screenshot? Weird.

in an elevated gpresult /r there is no "ISMS" GPO shown

the rsop report shows the setting being applied from the GPO "ISMS"

Well, i thought i read trough the gpresult very carefully, now im embarrassed.

Don't be. All this complex computer stuff, it sometimes gets over one's head :-)

thanks