I have an Exchange 2010 server which keeps disconnecting all users, and so far the workaround is to restart the Information Store. When reviewing the event logs, they show multiple 1008 events:
"Exchange ActiveSync has encountered repeated failures when it tries to access data on Mailbox server [server]. It will temporarily stop making requests to the Mailbox server for  seconds to reduce load on that server. This delay may occur if the Mailbox server is overloaded. If this event is logged frequently, review the Application log on this server and the Mailbox server noted above for other events that could indicate the root cause of performance problems.
Also seeing 1006 events:
Log Name: Application
Source: MSExchange Mailbox Replication
Date: 04/02/2018 09:39:06
Event ID: 1006
Task Category: Service
The Microsoft Exchange Mailbox Replication service was unable to process jobs in a mailbox database.
Database: Mailbox Database 1234072321
Error: MapiExceptionCallFailed: Unable to make connection to the server. (hr=0x80004005, ec=5)
These clear after the Information Store is restarted. The application log is so full of the 1008 errors prior to the restart, that there are no other events to help identify causation.
Any ideas as to what could be causing this?