'Signature' button not working in Outlook 2016

Hi Everyone,

I am requiring assistance with resolving an issue on a client's machine that I have not encountered before.

The client is running the following:
 - Windows 10 Pro 64 Bit
 - 16 GB RAM
 - Office 2016, 32 bit (Office 365)

The issue that is being experienced is that File > Options  > Mail > Signatures is not working. When the signatures button is selected, Outlook hangs for about 30 seconds before returning to normal as if the button has been pressed.

I've attempted an online repair, uninstall and reinstall, checked recently installed Windows updates and found non that appeared to be related and no new updates are available.
I've opened the application in safe mode and there was no change so it isn't an add-in.

Any assistance, or ideas, would be greatly appreciated.

Kind Regards,
Matt StreetAsked:
Who is Participating?
Matt StreetAuthor Commented:
Hi guys,

Thanks for all of the swift responses. Turns out you were all correct in some manner, there was another version of Outlook previously installed and running at the same time but was removed shortly before I connected. I believe this caused some issues in the registry but to be safe I created a new user profile and the issue was resolved after doing this.

Thanks for all the help!
JohnBusiness Consultant (Owner)Commented:
I read all that you did.

Make a new, test, Windows User Profile (Account). Log into the new Windows Account, set up Outlook and test.
Jose Gabriel Ortega CCEO J0rt3g4 Consulting ServicesCommented:
Repair Office,
then create a new profile.

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Ares KurkluSoftware EngineerCommented:
Is it possible that another version of Office/ Outlook is installed as well?
Jose Gabriel Ortega CCEO J0rt3g4 Consulting ServicesCommented:
You should remove all the versions, and try to install the 64 bits office on 64 bits machines :)

Here's a tool to remove all the versions
Hello ThereSystem AdministratorCommented:
Navigate here:
For 32-bit installation:

For 64-bit installation

Locate LocalServer32 and change the value to:
For 32-bit Office installation on 32-bit Windows and for 64-bit Office installation on 64-bit Windows:
C:\Program Files\Microsoft Office 16\root\Office16\Outlook.exe

For 32-bit Office installed on 64-bit Windows:
C:\Program Files(x86)\Microsoft Office 16\root\Office16\Outlook.exe
I had this issue happen on 3 new laptops. I tried the above fixes that worked on issues previously with no luck. What fixed it for me (Windows 10 1709 + latest Office 365, so Outlook 2016) was this (removing Microsoft Office Desktop Apps):


Edit: Fixed is the wrong word, it worked around the issue.
Note: The system log would throw this error when the issue was occurring:

The server {0006F03A-0000-0000-C000-000000000046} did not register with DCOM within the required timeout.
Seth SimmonsSr. Systems AdministratorCommented:
No comment has been added to this question in more than 21 days, so it is now classified as abandoned.

I have recommended this question be closed as follows:

-- Matt Street (https:#a42471272)
-- Jose Gabriel Ortega C (https:#a42461889)
-- John (https:#a42461869)

If you feel this question should be closed differently, post an objection and the moderators will review all objections and close it as they feel fit. If no one objects, this question will be closed automatically the way described above.

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