Windows 10 Inaccessible Boot Device

Windows 10 PC, boots to BSOD Inaccessible Boot Device.  Have cloned drive (In an attempt to repair) to new 1TB and ran SFC and CHKDSK.  Also removed any Sessions Pending from registry.  Note: No updates were Install pending.  Intel Pentium G860 CPU.  No BIOS updated had been performed to any ones knowledge.  I have no history with this client machine, so that is everything I know so far.  I have been booting to USB install media to run repairs.  No Restore points exist on the PC.
Jason JohanknechtIT ManagerAsked:
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JohnBusiness Consultant (Owner)Commented:
It would appear the original hard drive is corrupted or has a hardware issue.

Try to boot with a bootable USB Key and then see if you can run a disk test. You can usually get this test software ready to go from your computer manufacturer.
Peter HutchisonSenior Network Systems SpecialistCommented:
Run Diskpart tool from the command line and run 'select disk 0' and 'list partition'. There should be one or more partitions. Some times you may find a small EFI partition and then the main system partition with Windows on it.
On C: drive you should see c:\Boot folder and c:\bootmgr and this will be the drive to boot from. If these are damaged, you can try to rebuild the boot files using the BootRec command to try to fix the BCD file, MBR and boot disk.

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Jason JohanknechtIT ManagerAuthor Commented:
Great thought Peter, I didn't even think about that!

The original drive I suspected from beginning was the cause, and that is why I cloned it.  I am currently running a virus scan on the original drive while working on the installed clone.  SFC, CHKDSK, and DISM all successfully run on new drive, but no luck yet.
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JohnBusiness Consultant (Owner)Commented:
I think your original drive was damaged .
Jason JohanknechtIT ManagerAuthor Commented:
bootrec /rebuild shows [1] E:\Windows
but returns "The requested system device cannot be found"
Jason JohanknechtIT ManagerAuthor Commented:
John, I agree the drive was likely the cause.  Was hopeful, since the clone went through without any unreadable sectors.  Any other ideas?
JohnBusiness Consultant (Owner)Commented:
Cloning a bad drive normally does not work.

Try a disk test on the original drive. You may need a disk recovery service if you have important data on it.
Jackie Man IT ManagerCommented:
Your symptom suggested a ransomware attack of the old harddisk and all bootloader files are gone.

You need a fresh install of the OS.
Jason JohanknechtIT ManagerAuthor Commented:
Virus scan is still running (Norton Security), but it has found 6 virus infections so far.  I am checking with client to see if they had an active license for antivirus.
is the correct drive on top in the bios boot priority?
Jason JohanknechtIT ManagerAuthor Commented:
Yes, the boot priority was fine.  Viruses were all contained in unopened e-mails (Trash).  Was unable to repair using bootrec.  Computer was high priority and had to reset OS and reinstall all software.
Jason JohanknechtIT ManagerAuthor Commented:
Some good ideas were presented, but unfortunately a solution was not found.  The time line was short, and reset of the OS had to be used.  The new HDD and OS are working great so far.  Time will tell if something greater was the problem.

Thanks to both contributors.
JohnBusiness Consultant (Owner)Commented:
Thank you for the update
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