Windows 10 Randomly dropping use of keyboard and mouse

Randomly yesterday and today I have had two different locations with an 2-3 year old Dell and a brand new Dell have their keyboard and mouse stop working.

I checked Device Manager and the keyboard and mouse have a yellow exclamation point on them and the properties show "no compatible driver for this device".

I can remove the devices and re-detect, removed the USB controller and reinstalled and also updated USB and chipset drivers and BIOS with no solution?

I also don't see any recent Windows updates that should cause the issue.

Not sure what's going on here.
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truth_talkerConnect With a Mentor Author Commented:
I ended up finding a solution by removing Update KB4074588 and rebooting and USB keyboard/mouse started working again.
Hello ThereSystem AdministratorCommented:
Find and download any older driver for your devices that is compatible...
JohnBusiness Consultant (Owner)Commented:
Since you have updated drivers and BIOS, consider:

1. Updating Video to see if that helps.
2. Call Dell Support on the new machine (need tag number)

No issues like this on my or client Lenovo machines
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truth_talkerAuthor Commented:
There isn't a driver, it should be built into Windows.

I called Dell Support and they had no clue what was going on and are sending me a new mainboard.  But for two different model Dell's to have the same problem is odd.

I'm thinking a bad windows update or malware, maybe?
JohnBusiness Consultant (Owner)Commented:
Bad windows updates are down to Dell, not Microsoft.  

Malware?  Always, always a possibility with (sometimes) careless users. Scan with your AV and then follow with Malwarebytes.
RaminTechnical AdvisorCommented:
Try System Restore on one of those computers to check if it is software issue.
techplusConnect With a Mentor Commented:
I've had 3 computers do this in the last 24 hours. The first two were a client's computers, and I instinctively did system restores to later dates to get them going as quickly as possible. On both their computers, both the keyboard and mouse stopped working. Two completely different types of systems, one HP and one Dell, but both with Windows 10 I might add that one had a USB scanner and that was also showing no driver installed just like the mouse and keyboard, and wouldn't let me install driver. I had TeamViewer installed on both computers for remote support, so was able to remote in, which made things a LOT easier, since locally the mouse and keyboard weren't working. The third was one of my own computer this morning. I was working away, and just added a network printer, and immediately lost my mouse. I went in through TeamViewer and sure enough, the mouse was showing the exclamation point in Device manager, although the keyboard was working fine on this one. Same thing as the other two with the mouse. Tried updating driver and it said no driver found. Deleted it and it scanned for changes and it found it but again had the exclamation point. Removed USB controller from Device manager and scanned for changes, same thing. Restarting computer made no difference. Before resorting to system restore, I tried one last thing... DISABLED the mouse in device manager, then re-enabled, and it's worked ever since, even after restarting the computer. Wish I'd thought to try that on the other two. This might be worth a try in your case. Just not sure what caused it in the first place and keeping my fingers crossed that a bunch of my other clients don't have the same thing happen. Hope this helps someone out there. I couldn't find much at all on the online forums where it's happened to other people... I'm pretty sure it's happened to others if I had three computers do it myself.
Joe Winograd, Fellow&MVEConnect With a Mentor DeveloperCommented:
This problem has reached epidemic proportions, as all of these relatively recent EE threads show:'t-working-and-Malware.html't-work.html

The quick summary is to uninstall Windows update KB4074588.

Microsoft is well aware of the problem and even posted an article about it on 23-Feb at the Windows support site showing two methods to resolve it:

Regards, Joe
Joe Winograd, Fellow&MVEDeveloperCommented:
This is the infamous, now well-known KB4074588 bug. The asker figured it out and two other posts are very helpful. Splitting the points evenly among the three.
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